Richard Carthew Quantitative analysis of multicellular systems

Research Interests

Free-living cells navigate a challenging world using solitary solutions. In contrast, cells within a multicellular organism must act as a collective to carry out functions for the benefit of all. We study the unique and complex biology of cells in the context of tissues and organs. Model organisms such as the fruit fly Drosophila provide an unprecedented opportunity to understand the cell biology of multicellularity. Our lab uses a variety of high-throughput experimental tools such as genomics, genetics and quantitative imaging. We couple such data-intensive experiments with computational analysis and modeling. The goal is to gain a comprehensive and predictive understanding of how multicellular properties emerge from the collective of cells present in a tissue or organ. Such understanding has implications for diseases such as cancer, as well as methods of tissue regeneration to treat disease.

Selected Publications

Global constraints within the developmental program of the Drosophila wing. Alba V, Carthew JE, Carthew RW, and Mani M. eLife. 2021 June 28;10:e66750.

A pipeline for precise and efficient genome editing by sgRNA-Cas9 RNPs in Drosophila. Nyberg KG, Nguyen JQ, Kwon Y-J, Blythe S, Beitel GJ, and Carthew RW. Fly. 2020 October 21;14(1-4):34-48.

Ordered patterning of the sensory system is susceptible to stochastic features of gene expression. Giri R, Papadopoulos DK, Posadas DM, Potluri HK, Tomancak P, Mani M, and Carthew RW. eLife. 2020 February 26;9:e53638.

MicroRNA miR-7 Regulates Secretion of Insulin-Like Peptides. Agbu P, Cassidy JJ, Braverman J, Jacobson A, and Carthew RW. Endocrinology. 2020 February;161(2):bqz040.

Repressive Gene Regulation Synchronizes Development with Cellular Metabolism. Cassidy JJ, Bernasek SM, Bakker R, Giri R, Peláez N, Eder B, Bobrowska A, Bagheri N, Amaral LAN, and Carthew RW. Cell. 2019 August 8;178(4):P980-992.E17.

View all publications by Richard Carthew listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.