Vadim Backman Imaging for non-invasive screening, diagnosis & detection of disease, biological & bioengineered tissue

Research Interests

The main direction of our lab is the development of novel optical spectral and imaging techniques for non-invasive screening, diagnosis and detection of disease, and characterization of biological and bioengineered tissue. Our research spans from basic physics of light-tissue interaction to new technology development to the development of clinical instrumentation and to large-scale clinical trials.

Selected Publications

Macrogenomic engineering via modulation of the scaling of chromatin packing density. Almassalha LM, Bauer GM, Wu W, Cherkezyan L, Zhang D, Kendra A, Gladstein S, Chandler JE, VanDerway D, Seagle BL, Ugolkov A, Billadeau DD, O'Halloran TV, Mazar AP, Roy HK, Szleifer I, Shahabi S, and Backman V. Nature Biomedical Engineering. 2017 November 6;1:902-913.

The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene ExpressionAlmassalha LM, Tiwari A, Ruhoff PT, Stypula-Cyrus Y, Cherkezyan L, Matsuda H, Dela Cruz MA, Chandler JE, White C, Maneval C, Subramanian H, Szleifer I, Roy HK, and Backman V. Scientific Reports. 2017 January 24;7:41061.

Label-free imaging of the native, living cellular nanoarchitecture using partial-wave spectroscopic microscopyAlmassalha LM, Bauer GM, Chandler JE, Gladstein S, Cherkezyan L, Stypula-Cyrus Y, Weinberg S, Zhang D, Ruhoff PT, Roy HK, Subramanian H, Chandel NS, Szleifer I, and Backman V. PNAS. 2016 October 18;113(42):E6372-E6381.

Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography. Spicer GLC, Azarin SM, Yi J, Young ST, Ellis R, Bauer GM, Shea LD, and Backman V. Physics in Medicine and Biology. 2016 October 7;61(19):6892-6904.

Enhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo. Rao SS, Bushnell GG, Azarin SM, Spicer G, Aguado BA, Stoehr JR, Jiang EJ, Backman V, Shea LD, and Jeruss JS. Cancer Research. 2016 September 15;76(18):5209-5218.

View all publications by Vadim Backman listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.