Xiaomin Bao Gene regulation of human adult stem cell maintenance, tissue regeneration & disease

Research Interests

The majority of life-threatening cancers originated from epithelial tissue, a type of self-renewing somatic tissue that covers the surfaces and cavities of all human organs. Leveraging the human skin epidermis as a highly accessible research platform for integrating multi-disciplinary technologies (genomics, proteomics, imaging, metabolomics, and tissue engineering), we seek to uncover fundamental mechanisms governing human tissue regeneration and disease pathogenesis.

Selected Publications

Multi-omics integration identifies dell-state-specific repression by PBRM1-PIAS1 cooperation. Ho PJ, Kweon J, Blumensaadt LA, Neely AE, Kalika E, Leon DB, Oh S, Stringer CWP, Lloyd SM, Ren Z, Bao X. Genome Biology. 2015 December 18;16(1):284.

Nucleoporin downregulation modulates progenitor differentiation independent of nuclear pore numbers. Neely AE, Zhang Y, Blumensaadt LA, Mao H, Brenner B, Sun C, Zhang HF, and Bao X. Commun. Biol. 2023 October 18;6(1):1033

CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors. Lloyd SM, Leon DB, Brady MO, Rodriguez D, McReynolds MP, Kweon J, Neely AE, Blumensaadt LA, Ho PJ, and Bao X. Nature Communications. 2022 July 29;13:4408.

Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration. Chen X, Lloyd SM, Kweon J, Gamalong GM, and Bao X. Nature Communications. 2021 January 19;12:448.

Unwinding chromatin at the right places: how BAF is targeted to specific genomic locations during development. Ho PJ, Lloyd SM, and Bao X. Development. 2019 September 30;146(19):178780.

View all publications by Xiaomin Bao listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.