Xiaomin Bao Epigenomic regulation of stem cell maintenance & differentiation

Research Interests

The human body is composed of a variety of morphologically and functionally distinctive cell types, yet all of them share the same genome. My group is interested in investigating how genome organization and chromatin modification control spatial and temporal gene expression. Using human epidermal tissue as the primary research platform, we are actively exploring the epigenetic regulatory mechanism underlying stem cell maintenance and tissue differentiation, as well as studying how epigenetic dysregulation impacts human diseases.

The long-term goal of my group is to elucidate the gene regulatory mechanism of skin tissue homeostasis, and to provide new insights for human disease therapies.

Selected Publications

CSNK1a1 Regulates PRMT1 to Maintain the Progenitor State in Self-Renewing Somatic Tissue. Bao X, Siprashvili Z, Zarnegar BJ, Shenoy RM, Rios EJ, Nady N, Qu K, Mah A, Webster DE, Rubin AJ, Wozniak GG, Tao S, Wysocka J, and Khavari PA. Developmental Cell. 2017 October 23;43(2):227-239.e5.

A novel ATAC-seq approach reveals lineage-specific reinforcement of the open chromatin landscape via cooperation between BAF and p63Bao X, Rubin AJ, Qu K, Zhang J, Giresi PG, Chang HY, and Khavari PA. Genome Biology. 2015 December 18;16(1):284.

ACTL6a Enforces the Epidermal Progenitor State by Suppressing SWI/SNF-Dependent Induction of KLF4Bao X, Tang J, Lopez-Pajares V, Tao S, Qu K, Crabtree GR, and Khavari PA. Cell Stem Cell. 2013 February 7;12(2):193-203.

The COOH-terminal Domain of the JIL-1 Histone H3S10 Kinase Interacts with Histone H3 and Is Required for Correct Targeting to ChromatinBao X, Cai W, Deng H, Zhang W, Krencik R, Girton J, Johansen J, and Johansen KM. Journal of Biological Chemistry.2008 November 21;283(47):32741-32750.

The JIL-1 kinase interacts with lamin Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells. Bao X, Zhang W, Krencik R, Deng H, Wang Y, Girton J, Johansen J, and Johansen KM. Journal of Cell Science. 2005 November 1;118(21):5079-5087.

View all publications by Xiaomin Bao listed in the National Library of Medicine (PubMed).