Marco Gallio Processing of temperature stimuli in the brain

Research Interests

Our long term goal is to understand how sensory stimuli are used to build an internal representation of the physical world, and how this representation is in turn processed into our actions and behaviors. For this, our laboratory studies temperature sensing and preference in the fruit fly Drosophila. How are hot and cold stimuli detected at the periphery? How are they processed in the brain? How are they integrated with additional sensory streams and internal drives to produce behaviors such as attraction and avoidance? Using the fly as a model system is allowing us to study the basic principles of decision making and motivated behavior in an animal with only 100 thousand neurons (rather than our ~100 billion), and to take advantage of a highly sophisticated experimental toolkit.

Selected Publications

Activation of planarian TRPA1 by reactive oxygen species reveals a conserved mechanism for animal nociception. Arenas OM, Zaharieva EE, Para A, Vásquez-Doorman C, Petersen CP, and Gallio M. Nature Neuroscience. 2017 October 16;20(12):1686-1693.

Early Integration of Temperature and Humidity Stimuli in the Drosophila Brain. Frank DD, Enjin A, Jouandet GC, Zaharieva EE, Para A, Stensmyr MC, and Gallio M. Current Biology. 2017 August 7;27(15):2381-2388.e4.

Humidity Sensing in DrosophilaEnjin A, Zaharieva EE, Frank DD, Mansourian S, Suh GSB, Gallio M, and Stensmyr MC. Current Biology. 2016 May 23;26(10):1352-1358.

Dynamic labelling of neural connections in multiple colours by trans-synaptic fluorescence complementation. Macpherson LJ, Zaharieva EE, Kearney PJ, Alpert MH, Lin T-Y, Turan Z, Lee C-H, and Gallio M. Nature Communications. 2015 December 4;6:10024.

Temperature representation in the Drosophila brain. Frank DD, Jouandet GC, Kearney PJ, Macpherson LJ, and Gallio M. Nature. 2015 March 19;519(7543):358-361.

The Coding of Temperature in the Drosophila BrainGallio M, Ofstad TA, Macpherson LJ, Wang JW, and Zuker CS. Cell. 2011 February 18;144(4):614-624.

View all publications by Marco Gallio listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.