Robert A. Holmgren Cell-fate specification during development

Research Interests

Our laboratory studies Hedgehog signal transduction, which plays a central role in animal development and human disease.  The lab is focused on several areas: the identification and characterization of new pathway components, functional studies of the pathway, the analysis of non-canonical Hedgehog signaling in metabolism, and in collaboration with the Meade lab, the development of compounds to block Hedgehog signaling in cancer.

Selected Publications

Functional Disruption of Gli1-DNA Recognition via a Cobalt(III) Complex. Brue CR, Dukes MW, Masotti M, Holmgren R, and Meade TJ. ChemMedChem. 2022 April 20;17(8):e202200025.

Delivery of Targeted Co(III)–DNA Inhibitors of Gli Proteins to Disrupt Hedgehog Signaling. Dukes MW, Bajema EA, Whittemore TJ, Holmgren RA, and Meade TJ. Bioconjugate Chemistry. 2022 April 20;33(4):643-653.

Engrailed, Suppressor of fused and Roadkill modulate the Drosophila GLI transcription factor Cubitus interruptus at multiple levels. Roberto N, Becam I, Plessis A, and Holmgren RA. Development. 2022 March;149(6):dev200159.

Regulation of the RNA-binding protein Smaug by the GPCR Smoothened via the kinase Fused. Bruzzone L, Argüelles C, Sanial M, Miled S, Alvisi G, Gonçalves-Antunes M, Qasrawi F, Holmgren RA, Smibert CA, Lipshitz HD, Boccaccio GL, Plessis A, and Bécam I. EMBO Reports. 2020 July 3;21(7):e48425.

Dose-dependent transduction of Hedgehog relies on phosphorylation-based feedback between the G-protein-coupled receptor Smoothened and the kinase Fused. Sanial M, Bécam I, Hofmann L, Behague J, Argüelles C, Gourhand V, Bruzzone L, Holmgren RA, and Plessis A. Development. 2017 May;144(10):1841-1850.

View all publications by Robert Holmgren listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.