Yevgenia Kozorovitskiy Development, modulation, and functions of neurons and their synapses

Research Interests

The long-range goal of our lab is to accelerate the understanding of neuromodulation and plasticity in the vertebrate brain. Our studies will facilitate the development of therapeutic applications, harnessing the power of neuromodulators to functionally reconfigure, and sometimes even literally rewire, neural circuits.

Neuromodulation is biologically complex, requiring a diverse set of tools. We rely on 2-photon imaging and 2-photon neurotransmitter photorelease, whole-cell electrophysiology, electron microscopy, neuroproteomics, opto- and pharmacogenetics, neuroanatomical, transcriptional and behavioral analyses. We also work to develop and refine new optical imaging and synthetic biology techniques.

Selected Publications

Wireless multilateral devices for optogenetic studies of individual and social behaviors. Yang Y, Wu M, Vázquez-Guardado A, Wegener AJ, Grajales-Reyes JG, Deng Y, Wang T, Avila R, Moreno JA, Minkowicz S, Dumrongprechachan V, Lee J, Zhang S, Legaria AA, Ma Y, Mehta S, Franklin D, Hartman L, Bai W, Han M, Zhao H, Lu W, Yu Y, Sheng X, Banks A, Yu X, Donaldson ZR, Gereau RW, Good CH, Xie Z, Huang Y, Kozorovitskiy Y, and Rogers JA. Nature Neuroscience. 2021 July;24(7):1035-1045.

Ketamine Rapidly Enhances Glutamate-Evoked Dendritic Spinogenesis in Medial Prefrontal Cortex Through Dopaminergic Mechanisms. Wu M, Minkowicz S, Dumrongprechachan V, Hamilton P, and Kozorovitskiy Y. Biological Psychiatry. 2021 June 1;89(11):P1096-1105.

Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions. Wu M, Minkowicz S, Dumrongprechachan V, Hamilton P, Xiao L, and Kozorovitskiy Y. eLife. 2021 April 27;10:e64041.

Integrated one- and two-photon scanned oblique plane illumination (SOPi) microscopy for rapid volumetric imaging. Kumar M, Kishore S, Nasenbeny J, McLean DL, and Kozorovitskiy Y. Optics Express. 2018 May 14;26(10):13027-13041.

Biased Oxytocinergic Modulation of Midbrain Dopamine Systems. Xiao L, Priest MF, Nasenbeny J, Lu T, and Kozorovitskiy Y. Neuron. 2017 July 19;95(2):368-384.e5.

View all publications by Yevgenia Kozorovitskiy listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.