Yevgenia Kozorovitskiy Development, modulation, and functions of neurons and their synapses

Research Interests

The long-range goal of our lab is to accelerate the understanding of neuromodulation and plasticity in the vertebrate brain. Our studies will facilitate the development of therapeutic applications, harnessing the power of neuromodulators to functionally reconfigure, and sometimes even literally rewire, neural circuits.

Neuromodulation is biologically complex, requiring a diverse set of tools. We rely on 2-photon imaging and 2-photon neurotransmitter photorelease, whole-cell electrophysiology, electron microscopy, neuroproteomics, opto- and pharmacogenetics, neuroanatomical, transcriptional and behavioral analyses. We also work to develop and refine new optical imaging and synthetic biology techniques.

Selected Publications

Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment. Dumrongprechachan V, Salisbury RB, Butler L, MacDonald ML, and Kozorovitskiy Y. eLife. 2022 October 14;11:e78847.

Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology. Wu Y, Wu M, Vázquez-Guardado A, Kim J, Zhang X, Avila R, Kim J-T, Deng Y, Yu Y, Melzer S, Bai Y, Yoon H, Meng L, Zhang Y, Guo H, Hong L, Kanatzidis EE, Haney CR, Waters EA, Banks AR, Hu Z, Lie F, Chamorro LP, Sabatini BL, Huang Y, Kozorovitskiy Y, and Rogers JA. Nature Communications. 2022 September 22;13:5571.

Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum. Dumrongprechachan V, Salisbury RB, Soto G, Kumar M, MacDonald ML, and Kozorovitskiy Y. Nature Communications. 2021 August 11;12:4855.

Wireless multilateral devices for optogenetic studies of individual and social behaviors. Yang Y, Wu M, Vázquez-Guardado A, Wegener AJ, Grajales-Reyes JG, Deng Y, Wang T, Avila R, Moreno JA, Minkowicz S, Dumrongprechachan V, Lee J, Zhang S, Legaria AA, Ma Y, Mehta S, Franklin D, Hartman L, Bai W, Han M, Zhao H, Lu W, Yu Y, Sheng X, Banks A, Yu X, Donaldson ZR, Gereau RW, Good CH, Xie Z, Huang Y, Kozorovitskiy Y, and Rogers JA. Nature Neuroscience. 2021 July;24(7):1035–1045.

Ketamine Rapidly Enhances Glutamate-Evoked Dendritic Spinogenesis in Medial Prefrontal Cortex Through Dopaminergic Mechanisms. Wu M, Minkowicz S, Dumrongprechachan V, Hamilton P, and Kozorovitskiy Y. Biological Psychiatry. 2021 June 1;89(11):1096-1105.

View all publications by Yevgenia Kozorovitskiy listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.