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Submenu for: PeopleThomas J. Meade Bioinorganic coordination chemistry, biological molecular imaging, transcription factor inhibitors, electronic biosensors
Research Interests
The Meade Lab research focuses on bioinorganic coordination chemistry in three subgroups:
- Molecular imaging of in vivo gene expression and intracellular messengers
- The development of inhibitors of Zinc-finger transcription factors
- Creating electronic biosensors for the detection of proteins and DNA
Selected Publications
Delivery of Targeted Co(III)-DNA Inhibitors of Gli Proteins to Disrupt Hedgehog Signaling. Dukes MW, Bajema EA, Whittemore TJ, Holmgren RA, and Meade TJ. Bioconjugate Chemistry. 2022 April 20;33(4):643-653.
Modulation of Hedgehof Signaling for the Treatment of Basal Cell Carcinoma and the Development of Preclinical Models. Dukes MW, and Meade TJ. Biomedicines. 2022 September 23;10(10):2376.
Chapter 9: Non-invasive Detection of Stem Cell Therapies Facilitated by Metal Ion-Based Contrast Agents. Meade TJ (2022). In Molecular Bio-Sensors and the Role of Metal Ions. (ed T.J. Meade) 1st edition. CRC Press: 261.
Molecular Bio-Sensors and the Role of Metal Ions. Meade TJ (2022). CRC Press.
Engineered Nonviral Protein Cages Modified for MR Imaging. Kaster MA, Levasseur MD, Edwardson TGW, Caldwell MA, Hoffmann D, Licciardi G, Giacomo P, Luchinat C, Hilvert D, and Meade TJ. ACS Appl. Bio. Mater. 2023 January 10;6(2):591-602.
Molecular Engineering of Self-Immolative Bioresponsive MR Probes. Tang JH, Li H, Yuan C, Parigi G, Luchinat C, and Meade TJ. J. Am. Chem. Soc. 2023 April 28;145(18):10045-10050.
Musculoskeletal imaging of senescence. Daldrup-Link HE, Suryadevara V, Tanyildizi Y, Nernekli K, Tang JH, and Meade TJ. Skeletal Radiology. 2024 February 8;Published online.
Development of Ln(III) Derivatives as 19F Parashift Probes. Kaster MA, Caldwell MA, and Meade TJ. Inorg. Chem. 2024 May 15; 63(21):9877-9887.
View all publications by Thomas J. Meade listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.