Thomas J. Meade Bioinorganic coordination chemistry, biological molecular imaging, transcription factor inhibitors, electronic biosensors

Research Interests

The Meade Lab research focuses on bioinorganic coordination chemistry in three subgroups:

  1. Molecular imaging of in vivo gene expression and intracellular messengers
  2. The development of inhibitors of Zinc-finger transcription factors
  3. Creating electronic biosensors for the detection of proteins and DNA

Selected Publications

Functional Disruption of Gli1-DNA Recognition via a Cobalt(III) Complex. Brue CR, Dukes MW, Masotti M, Holmgren R, and Meade TJ. ChemMedChem. 2022 April 20;17(8):e202200025.

Delivery of Targeted Co(III)-DNA Inhibitors of Gli Proteins to Disrupt Hedgehog Signaling. Dukes MW, Bajema EA, Whittemore TJ, Holmgren RA, and Meade TJ. Bioconjugate Chemistry. 2022 April 20;33(4):643-653.

Towards Imaging Pt Chemoresistance Using Gd(III)-Pt(II) Theranostic MR Contrast Agents. Adams CJ and Meade TJ. ChemMedChem. 2021 December 14;16(24):3663-3671.

Real-time MR tracking of AAV gene therapy with βgal-responsive MR probe in a murine model of GM1-gangliosidosis. Taghian T, Batista AR, Kamper S, Caldwell M, Lilley L, Li H, Rodriguez P, Mesa K, Zheng S, King RM, Gounis MJ, Todeasa S, Maguire A, Martin DR, Sena-Esteves M, Meade TJ, and Gray-Edwards HL. Molecular Therapy Methods and Clinical Development. 2021 December 10;23:128-134. 

Magnetic Resonance Imaging of PSMA-Positive Prostate Cancer by a Targeted and Activatable Gd(III) MR Contrast Agent. Li H, Luo D, Yuan C, Wang X, Wang J, Basilion JP, and Meade TJ. Journal of the American Chemical Society. 2021 October 20;143(41):17097-17108.

View all publications by Thomas J. Meade listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.