Xiaozhong (Alec) Wang Epigenetic regulation of mouse embryonic stem cells

Research Interests

The Wang lab uses genomics approaches to investigate regulatory pathways in mammalian stem cells.  Using mouse embryonic stem cells as a model system, our general experimental approach is to gain mechanistic insights by constructing both genetic interaction and protein-protein interaction maps of a key regulatory network.  We are currently working on two projects. First, we are investigating how nucleosomes encode epigenetic information to influence gene expression using a chemical biology approach.  Second, we are interested in how RNA repair pathways control cellular stress responses.

Selected Publications

The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress. Unlu I, Lu Y, and Wang X. Journal of Biological Chemistry. 2018 December 14;293(50):19365-19376.

Genome-wide Mapping of the Nucleosome Landscape by Micrococcal Nuclease and Chemical Mapping. Voong LN, Xi L, Wang J-P, and Wang X. Trends in Genetics. 2017 August;33(8):495-507.

Insights into Nucleosome Organization in Mouse Embryonic Stem Cells through Chemical Mapping. Voong LN, Xi L, Sebeson AC, Xiong B, Wang J-P, and Wang X. Cell. 2016 December 1;167(6):1555-1570.

A Synthetic Biology Approach Identifies the Mammalian UPR RNA Ligase RtcB. Lu Y, Liang F-X, and Wang X. Molecular Cell. 2014 September 4;55(5):758-770.

Mammalian hyperplastic discs Homolog EDD Regulates miRNA-Mediated Gene Silencing. Su H, Meng S, Lu Y, Trombly MI, Chen J, Lin C, Turk A, and Wang X. Molecular Cell. 2011 July 8;43(1):97-109.

View all publications by Xiaozhong Wang listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.