Hao F. Zhang Multi-scale imaging from the whole human eye to single molecules to understand vision and blinding diseases

Research Interests

The Zhang lab has pioneered two key technologies: visible-light optical coherence tomography (vis-OCT) and spectroscopic single-molecule localization microscopy (sSMLM). These technologies enable multi-scale investigation of a broad range of biomedical questions, ranging in scale from single molecules to whole human eyes. We apply our unique techniques to both clinical diagnosis and fundamental investigations.

Selected Publications

In Vivo Imaging of Schlemm's Canal and Limbal Vascular Network in Mouse Using Visible-Light OCT. Zhang X, Beckmann L, Miller DA, Shao G, Cai Z, Sun C, Sheibani N, Liu X, Schuman J, Johnson M, Kume T, and Zhang HF. Investigative Ophthalmology & Visual Science. 2020 February;61(2):23.

Speckle reduction in visible-light optical coherence tomography using scan modulation. Rubinoff I, Beckmann L, Wang Y, Fawzi AA, Liu X, Tauber J, Jones K, Ishikawa H, Schuman JS, Kuranov R, and Zhang HF. Neurophotonics. 2019 October;6(4):041107.

Three-dimensional biplane spectroscopic single-molecule localization microscopy. Song K-H, Zhang Y, Wang G, Sun C, and Zhang HF. Optica. 2019 June 20;6(6):709-715.

Increased Retinal Oxygen Metabolism Precedes Microvascular Alterations in Type 1 Diabetic Mice. Liu W, Wang S, Soetikno B, Yi J, Zhang K, Chen S, Linsenmeier RA, Sorenson CM, Sheibani N, and Zhang HF. Investigative Ophthalmology & Visual Science. 2017 February;58(2):981-989.

Optical Detection of Early Damage in Retinal Ganglion Cells in a Mouse Model of Partial Optic Nerve Crush Injury. Yi J, Puyang Z, Feng L, Duan L, Liang P, Backman V, Liu X, and Zhang HF. Investigative Ophthalmology & Visual Science. 2016 October;57(13):5665-5671.

Super-resolution spectroscopic microscopy via photon localization. Dong B, Almassalha L, Urban BE, Nguyen T-Q, Khuon S, Chew T-L, Backman V, Sun C, and Zhang HF. Nature Communications. 2016 July 25;7:12290.

View all publications by Hao F. Zhang in the National Library of Medicine (PubMed). Current and former IBiS students in blue.